The expression of the ligand of PD-1 (i.e., PD-L1) on the surface of osteosarcoma was reported [77], and in our research, interferon gamma (IFN-γ), which is one of the inflammatory cytokines, increases the expression of PD-L1 on the surface of osteosarcoma in vitro [78]. Here, IFNG is linked to osteosarcoma.