In order to select the studies, we performed a PubMed search using the keywords “stroke” and “Nrf2,” considering the experimental studies published from 2015 that evaluated in in vivo stroke models, both in vivo and in vitro stroke models or in microglia and astrocyte in vitro models the efficacy of the natural compounds showing the involvement of Nrf2. This evidence concerns the gene NFE2L2 and stroke disorder.