SPINK5 and Alzheimer disease: For example, data from the study by Nishio et al. showed that five missense mutations, such as Asn368Ser, Asp386Asn, and Glu420Lys were associated with AD.[6] However, Jongepier and his colleagues demonstrated that SPINK5 was not associated with atopic phenotypes in individuals ascertained by a proband with asthma.[7] Thus, the association of AD with SPINK5 polymorphisms remains unclear, and results are not conclusive.