Previous studies had reported that ion channel-associated gene such as PRELP, CLIC2, SCN2B, COL1A1-2, COMP and KCNJ5 play important roles in related bioprocesses.[21–23] Purpose of this article is to find the HUB genes between hypertension and LV remodeling, underlining regulation effects by TFs on differential gene expression. This evidence concerns the gene PRELP and Hypertension.