Previous studies had reported that ion channel-associated gene such as PRELP, CLIC2, SCN2B, COL1A1-2, COMP and KCNJ5 play important roles in related bioprocesses.[21–23] Purpose of this article is to find the HUB genes between hypertension and LV remodeling, underlining regulation effects by TFs on differential gene expression. The gene discussed is PRELP; the disease is hypertensive disorder.