Previous studies had reported that ion channel-associated gene such as PRELP, CLIC2, SCN2B, COL1A1-2, COMP and KCNJ5 play important roles in related bioprocesses.[21–23] Purpose of this article is to find the HUB genes between hypertension and LV remodeling, underlining regulation effects by TFs on differential gene expression. Here, SCN2B is linked to hypertensive disorder.