By comparing DEGs in hypertensive and uncontrolled hypertensive patients with hypertensive patients with or without LV remodeling samples, we predict that SEC14L3, EML7, PSMD7, PSMA1, GLRX, CNOT10, NBR1, DUSP12, STRAP, SMIM14, RBM8A, TMEM59, TMEM87A,PSMC1, CASP4, ITGB8, DNAJA1, PINK1, PRNP, SAP30L, and EIF3M may play roles in hypertension development. Here, CASP4 is linked to hypertensive disorder.