Although at the early stage of RVH, overall cardiac function was relatively retained, its biological effects were highlighted by altered bioenergetic metabolism, including elevated cellular apoptosis, autophagy, and mitochondrial degradation signals, and hindered mitochondrial respiratory-chain subunit proteins production.[28] In the present study, PSMD7, PSMC1, DNAJA1 and PINK1 are all up-regulated, which probably lead to hypertension progression and left ventricular remodeling through ATP-dependent degradation of ubiquitinated proteins or phosphorylating mitochondrial proteins. The gene discussed is PSMC1; the disease is hypertensive disorder.