The orexin projection system includes the lateral hypothalamus, reticular activating structure, and ventrolateral preoptic nucleus that were related to the pathogenesis of narcolepsy.[3] Narcolepsy type 2 was diagnosed, and the EDS of the patient was relieved immediately after surgical removal of the glioma from the hippocampus area of the right anteromedial temporal lobe. The gene discussed is HCRT; the disease is glioma.