HCRT and central nervous system cancer: The orexin projection system includes the lateral hypothalamus, reticular activating structure, and ventrolateral preoptic nucleus that were related to the pathogenesis of narcolepsy.[3] Narcolepsy type 2 was diagnosed, and the EDS of the patient was relieved immediately after surgical removal of the glioma from the hippocampus area of the right anteromedial temporal lobe.