We analyzed eight ST-EPN samples, covering ST-RELA (n = 5), ST-YAP1 (n = 1), and two subsequent recurrent surgical samples of a patient with ST-EPN (BT1030, CPDM0785) classified as PF-A by methylation profiling despite clear supratentorial midline location of the primary tumor (see Fukuoka et al., 2018) (Figure 1A). The gene discussed is YAP1; the disease is neoplasm.