As previous reports described a putative role of candidate EPN oncogenes in the generation of high-grade glioma-like tumors in murine models (Mohankumar et al., 2015; Johnson et al., 2010; Taylor et al., 2005), we next aimed at comparing developmental hierarchies of EPN with other high-grade gliomas using our primary, human tumor-derived scRNA-seq dataset. This evidence concerns the gene MME and neoplasm.