ERVW-1 and mal de Meleda: Their reported HIV mutation spectrum for MDM infections (G→A = 35%, A→G = 18%, A→T = 17%, A→C = 11%) does not differ significantly from the profile obtained in our selective sequencing of a 500 bp amplicon covering the V3 and V4 regions of env, which is known to be highly variable (Fig 5B) [38,39].