In fact, 3 heterozygous RyR2 LOF missense mutations, p.I4855M, p.A4860G, and p.S4938F, have now been demonstrated recently to cause autosomal dominant left ventricular noncompaction with atypical CPVT, cIVF, or “short-coupled torsades de pointes ventricular arrhythmia,” respectively (6, 13–15). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.