Interestingly, 1 of the 4 patients classified as having cIVF (i.e., negative Holter and/or exercise stress test), a 7-year-old girl presenting with syncope, had the p.A4860G-RyR2 variant that was demonstrated most recently to confer a loss of function (LOF) to the RyR2/CRC and lead to the formation of early afterdepolarizations (EADs) (12). The gene discussed is RYR2; the disease is colorectal carcinoma.