However, IκB-α blocks specific DNA binding activity of the NF-κB transcription factor.20 Treatment of LG, CT, or FCT to AOM/DSS-induced CAC mice revealed that the mRNA expression and protein production of β-catenin and NF-κB reduced significantly compared to the AOM/DSS control group (Figure 4(c)). The gene discussed is NFKB1; the disease is infectious otitis media.