GSK3B and Parkinson disease: Among the hybrids, 5 and 6 proved to effectively inhibit GSK-3β, while 4 and 5 showed a marked ability to activate Nrf2together to increase the neuronal resistance to oxidative stress.These last pieces of evidence translated into specific neuroprotectiveeffects of 4 and 5 against PD pathologicalevents including neurotoxicity elicited by α-synuclein aggregatesand 6-hydroxydopamine.