Theenzyme GSK-3, a multifunctional serine/threonine kinase, existsin two isoforms, i.e., GSK-3α and GSK-3β, and participatesin a wide range of cellular processes and signaling pathways; itsincreased expression and activity have been observed in several NDDsincluding AD and PD. This evidence concerns the gene GSK3B and Parkinson disease.