NFE2L2 and Alzheimer disease: The Keap1/Nrf2/ARE complex directly regulatesthe expression of some phase II detoxifying enzymes and antioxidantstress genes, namely NAD(P)H: quinone oxidoreductase 1 (NQO1), hemeoxygenase-1, glutathione S-transferase, and aldo-keto reductase.7 Further, Nrf2 ameliorates the inflammation responseby inhibiting the translocation of nuclear factor-kB (NF-kB) and activatinganti-inflammatory genes.8,9 An altered expressionof Nrf2 in both neurons and astrocytes of PD and AD patients has beenobserved.