Inparticular, oxidative stress is implicated in the proteostasisphenomena and leads to misfolding of neurotoxic proteins such as α-synuclein(α-syn) in Lewy bodies (LBs) of PD and phospho-tau (p-tau) andamyloid-β (Aβ) in neurofibrillary tangles and senile plaques,respectively, of AD.4 This evidence concerns the gene MAPT and Alzheimer disease.