More recent studies suggest that Nrf2 activation reducesα-syn and p-tau levels, facilitating the degradation of thesetoxic proteins through autophagy.10−12 Thus, the Nrf2 signalingcascade, as a valuable defense against oxidative stress insults andloss of proteostasis, has been recognized as a validated target forthe development of therapeutics for PD and AD treatment. This evidence concerns the gene NFE2L2 and Alzheimer disease.