The most commonly used medications contributing to polypharmacy reflect the treatment of medical conditions previously found to be associated with job strain including cardiovascular disease (beta blockers, lipid modifying agents, antithrombotics, ACE inhibitors), mental disorders (antidepressants, hypnotics and sedatives), gastroesophageal disease (drugs for peptic ulcer and gastro-oesophageal disease), and musculoskeletal and pain disorders (opioids and other analgesics). The gene discussed is ACE; the disease is cardiovascular disorder.