The most prevalent medications contributing to polypharmacy at follow-up were beta blockers (ATC code: C07A), lipid modifying agents (C10A), antithrombotic agents (B01A), antidepressants (N06A), hypnotics and sedatives (N05C), drugs for peptic ulcer and gastro-oesophageal disease (A02B), opioids (N02A), calcium channel blockers (C08C), angiotensin-converting enzyme (ACE) inhibitors (C09A), and other analgesics (N02B). This evidence concerns the gene ACE and peptic ulcer disease.