Huang et al. reported that miR-133b was noticeably descended in ESCC tumor tissues and all kinds of ESCC cell lines, and the overexpression of miR-133b remarkably contribute to inhibit the proliferation and advance the apoptosis of Eca-109 and KYSE150 cells by targeting cullin 4B [40]. This evidence concerns the gene CUL4B and esophageal squamous cell carcinoma.