After release and restoration of the blood supply, the cell contents including nephrotoxicity myoglobin (Mb), urate, phosphate, potassium, etc. are released into the blood circulation [6], which eventually lead to myoglobinuria, acute kidney injury (AKI), electrolyte metabolic disorders, hypovolemic shock, multiple organ dysfunction syndrome (MODS), and so on [7]. The gene discussed is MB; the disease is acute kidney injury.