Inhalation, in contrast to intravenous administration of sGC-activators and stimulators, has been shown to give selective pulmonary vasodilatation in awake lambs with acutely thromboxane-induced pulmonary hypertension.26 Still, such an application has not to our knowledge been tested in humans or healthy animals. Here, SGCB is linked to pulmonary arterial hypertension.