Furthermore, in colorectal cancer cell lines, D‐glucose activates Caco‐2 BB NHE3 through p38‐MAP kinase, MAPAKP2, PI3‐K and AKT2, and endothelin also affects the Ca2+‐sensitive kinase PYK2 in a dose‐dependent manner. This evidence concerns the gene SLC9A3 and colorectal cancer.