SHANK2 mutation has been recently linked to autism (Berkel et al., 2010; Won et al., 2012; Schneider et al., 2014), and SHANK2 expression is mostly restricted to the nervous system (Naisbitt et al., 1999; Hayashi et al., 2009; Berkel et al., 2010; Won et al., 2012; Schneider et al., 2014). Here, SHANK2 is linked to autism.