VCL and dilated cardiomyopathy: Several mutations in metavinculin had been associated with dilated cardiomyopathy, with the Arg975Trp mutation resulting in large aggregates of actin filaments together with irregular and fragmented intercalated discs, supporting the notion that disrupted impaired contractile force transmission can lead to dilated cardiomyopathy (Olson et al. 2002).