In a healthy heart, PKCα is inhibited by MLP, but in the hearts of MLP knockout mouse (Ehler et al. 2001) and of human patients with dilated cardiomyopathy where MLP expression is reduced (Zolk et al. 2000), the inhibition is released and PKCα translocates to the intercalated disc, becoming part of a multiprotein complex consisting of cardiac-specific ankyrin repeat protein1 (CARP1), CARP2 and phospholipase C β1 (PLCβ1) (Lange et al. 2016). This evidence concerns the gene PRKCA and dilated cardiomyopathy.