In the muscle LIM protein (MLP, also called Csrp3)-knockout mouse, a model for dilated cardiomyopathy, the levels of α-catenin, vinculin and F-actin were increased at the intercalated disc, which could well be an adaptive response in supporting the increased mechanical load of the failing heart (Ehler et al. 2001). The gene discussed is CSRP3; the disease is dilated cardiomyopathy.