However, it is speculated that cardiac injury can occur through one or more of the putative mechanisms [28, 70, 71]: direct invasion by the virus, indirect damage due to the systemic inflammatory syndrome and cytokine storm, dysregulation of renin-angiotensin-aldosterone system, hypoxia-induced cardiac injury, microvasculature damage of the heart, stress-induced cardiomyopathy, and cardiac damage secondary to multi-organ failure. Here, REN is linked to Tako-tsubo cardiomyopathy.