After 12 weeks of EOJ consumption, we observed a decrease in PBMC expression of two key hypertension-related genes: PTX3 and NAMPT. Serum levels of PTX3, a marker of inflammation activation, are elevated in hypertensive patients [45], and experimental studies reported a direct role of PTX3 in vascular function and BP homeostasis [46]. Here, NAMPT is linked to hypertensive disorder.