Urinary TCF21 concentration was statistically significant among each glomerular disease, and showed a positive correlation among each glomerular disease (Fig. 2b, p < 0.01, with severity of proteinuria; 0.03 ± 0.03 g/gCre in healthy volunteers, 0.7 ± 0.5 g/gCre in NGD, 1.4 ± 1.5 g/gCre in IgAN, 6.2 ± 2.2 g/gCre in FSGS, 7.9 ± 3.2 g/gCre in MCD and 6.8 ± 4.6 g/gCre in MGN). Here, TCF21 is linked to focal segmental glomerulosclerosis.