SIX1 and obesity due to melanocortin 4 receptor deficiency: Also consistent with previous reports, we confirmed differences between ScAT and VAT in gene expression patterns including not only developmental genes, but also genes potentially contributing to aberrant adipocyte function during obesity such as SIX1, which binds to adipogenic and brown marker genes and interacts with C/EBPα, C/EBPβ, and EBF2 [30].