The peroxisome proliferator-activated receptor (PPAR) pathway and several inflammatory pathways, such as NF-κB and JAK/STAT, which are known to be important in CML LSC maintenance [19–25], are also affected by STAP-1 ablation (Fig. 5b, c). This evidence concerns the gene SOAT1 and chronic myelogenous leukemia, BCR-ABL1 positive.