NR1H4 and gestational diabetes: Hepatic FXR function is reduced in normal pregnancy as a consequence of raised concentrations of reproductive hormones, including progesterone sulphates22 and 17β‐estradiol23, and levels of progesterone sulphates are even higher in cholestatic pregnancies24, suggesting that gestational alterations in FXR signalling may contribute to susceptibility to GDM in ICP.