Recent study by Helmke et al. showed CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and was responsible for PD-induced peritoneal fibrosis23 Although hypochlorite is a fast and efficient method to induce PF; however, its molecular and cellular mechanisms were not fully understood and was considered as a “non-clinical relevant” approach to re-create PF in human patients. This evidence concerns the gene CX3CL1 and pemphigus foliaceus.