GABRB3 and psychiatric disorder: In order to test the functional significance of co-transplantation of human PVECs with interneurons, when compared to interneuron-only transplants, we used a well-established pre-clinical model of psychiatric disorder—the Gabrb3 endothelial cell conditional knockout model (Gabrb3ECKO mice), in which there are both vascular and GABAergic interneuron deficits in the cingulate, motor, and somatosensory cortex [15].