MAP1LC3B and hepatocellular carcinoma: On the other hand, DRP1 overexpressing in hypoxic HCC cells (HepG2, MHCCLM3) resulted in increased mitophagy-related protein BNIP3, LC3B and decreased p62 in mitochondrial fraction (Fig. 3e), demonstrating that upregulation of DRP1 can promote mitophagy.