CASP3 and hepatocellular carcinoma: DRP1 overexpression resulted in reduced apoptosis in hypoxia HCC cells (Fig. 3f), which resulted from decreased mitochondrial accumulation of Bax (Fig. 3g), lesser mitochondrial membrane potential loss (Fig. 3h), a lesser cytochrome c and AIF release from the mitochondria, and a decreased cleaved caspase-3 (Fig. 3g).