DNM1L and hepatocellular carcinoma: More importantly, DRP1 inhibition by Mdivi-1 significantly suppressed hypoxia-induced mitochondrial fission and mitophagy in HCC cells, as indicated by the increased normal tubular (not fragmented) mitochondrial morphology (Fig. 2a), and a reduction of yellow puncta containing lysosome with mitochondria (Fig. 2b), and a prominent reduction in visual analysis of mitophagic flux (red fluorescence) (Fig. 2c).