Compared to either single knockout, we observed that double knockout of Brd9&Jmjd6 and Kat6a&Jmjd6 were associated with stronger transcriptional changes of two gene sets linked to leukemia stem cell and myeloid differentiation programs, both of which are essential regulatory programs for leukemia survival20 (Supplementary Fig. 18b). The gene discussed is BRD9; the disease is leukemia.