However, knockout of Hsp27 blocks hnRNPA1 cytosol relocolization, indicating a fundamental role of Hsp27 in regulating the import/export of nuclear proteins during virus infection (Fig. 6).383 Hsp27 is rapid upregulated at the early stage (4 hours post infection) of coronavirus infection,387 suggesting an important role in virus early replication and possibly a good target for treating SARS-CoV-2 infection. Here, HSPB2 is linked to viral infectious disease.