CXCL8 and adenoviridae infectious disease: Adenovirus infection causes a wide variety of diseases.390 The internalization of Adenovirus leads to the activation of ERK1/2, which could in turn trans-activate NF-κB and AP-1 to induce pro-inflammatory cytokine IL-8 expression in different experimental systems.391–393 A study shows that downregulation of Hsp27 leads to an increased release of IL-8 from keratinocytes stimulated with UV or TNFα.