The RNA replication of HCV needs the presence of hnRNP I, hnRNP C;437,442,446 while virus RNA translation requires hnRNP A1, hnRNP D, hnRNP I, hnRNP K and hnRNP L.452,460,462–465 Besides, hnRNP A2, hnRNP L, hnRNP U and hnRNP K are highly expressed in HCC tissue. The gene discussed is HNRNPK; the disease is hepatocellular carcinoma.