HSPB3 and infection: Also, Hsp27 enhances viral IRES activity by promoting 2Apro - mediated EIF4G cleavage.57 Interestingly, the nuclear translocation of Hsp27 from cytosol is reversely correlated with the relocalization of RNA chaperone hnRNPA1 from nucleus to the cytosol for initiating viral protein translation upon EV-A71 infection.