Further studies show that OM suppresses the viral IRES-mediated translation of polypeptide via suppressing ERp57, and ectopic expression of ERp57 increases the IRES activity and partially rescues the decreased viral replication caused by OM treatment.415 The detailed mechanism how ERp57 downregulates IRES activity would be further investigated. The gene discussed is PDIA3; the disease is ocular melanoma.