The integrase catalyzes the integration of HIV-1 pro-viral DNA in the host genome.337 A small portion of Hsp60 colocalizes and interacts with the viral integrase (IN).338 Hsp60-Hsp10 complex maintains the integrase at an active form and stimulates its activity in an ATP-dependent manner.338 The integration is a critical step for successful infection of HIV-1. The gene discussed is HSPD1; the disease is infection.