DNAJB6 and HIV-1 infection: Some components of PIC implicated in regulating nuclear import include the central DNA flap and viral proteins IN, MA, and Vpr of HIV-1 (or Vpx of HIV-2).288,368–372 Hsp40/DnaJB6 interacts and enhances the nuclear localization of Vpx as well as promotes the nuclear import of viral PIC.373 Similarly, DnaJB6 also promotes Vpr nuclear localization during HIV-1 infection;374,375 particularly, the long isoform of DnaJB6 is extremely important in this process.375 The expression level of DNAJB6 S/L isoform is regulated by the polyadenylation factor CstF64.