HSPD1 and neoplasm: Myrtucommulone A (MC) binds to Hsp60 and inhibits the refolding activity of the Hsp60-Hsp10 complex.686 MC is a non-prenylated acylphloroglucinol with multiple reported bioactivities, including antibacterial,687,688 antioxidant,689 anti-inflammatory,690,691 and anti-tumor properties.692,693 In addition to these natural products, several other natural products are also reported to interact with Hsp60 without direct proof.