MAPT and early-onset autosomal dominant Alzheimer disease: The combination of histochemical methods (Fig. 1a, Gallyas staining, frontal cortex, cerebellum hippocampal hilus, and dentate gyrus, and Fig. S4, hypothalamus and olfactory bulb) and immunohistochemistry (hippocampal hilus and dentate gyrus, with antibodies recognizing Alzheimer’s disease-related hyperphosphorylated Tau AT8 and AT180, Fig. 1a, dashed blue box)15 identified extensive tauopathy.