In this respect, ADNP, regulating its own expression27, has been implicated in brain function (ID) affecting all known ADNP syndrome cases6 with motor impediments correlated in severity to ID, endocrine problems (24.5% of the children/thyroid hormone problem, 15%), early puberty (30%), skin problems, gastrointestinal problems (83% of the children), and urogenital problems (28%)6. Here, ADNP is linked to ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.