H3C2 and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: In contrast to the listed gene transcripts above, histone cluster 1 H3 family member B (HIST1H3B) that encodes a nucleosome core protein, showed a relatively high expression in the ADNP syndrome cerebellum and pituitary (hypophysis), and a decreased expression in the hippocampus, indicating gene specificity.