Interestingly, ADNP/NAP preferentially interact with the alternatively spliced three microtubule binding repeat dynamic Tau (associated with development) compared with four microtubule binding repeat Tau17 implicating potential early onset tauopathy in association with the ADNP syndrome. The gene discussed is ADNP; the disease is ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.