ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: Furthermore, using RNA-seq on EBV-transformed human lymphoblastoid cell lines from a healthy control and from three ADNP syndrome patients, carrying three different mutations, we discovered ADNP-dependent altered gene regulation that was also mimicked by our Adnp-deficient mouse model10,18 and was correlated with the finding of this very early onset tauopathy.