SDC4 and osteoarthritis: SDC4 (Syndecan-4), a target of miR-140-3p.2 but not miR-140-3p.1, has been implicated in osteoarthritis progression through activation of ADAMTS5 (Echtermeyer et al. 2009), suggesting SDC4 suppression by miR-140-3p.2 may maintain a healthy cartilage phenotype.