HMGCR and breast cancer: HMGCR and HMGCS1 have now been identified as targets of miR-140-3p.1 in breast cancer cells (Bhardwaj et al. 2018); however, their expression was not repressed by miR-140-3p.1 in human chondrocytes, indicating miR-140 isomiRs act in a tissue-specific manner.