Various anabolic factors, including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), IGF, TGF-β and the anti-inflammatory cytokines soluble tumor necrosis factor receptor type II (sTNF-RII), IL-4 and IL-10, have been noted in APS [46]. This evidence concerns the gene IL4 and autoimmune polyendocrinopathy.