On the other hand, miR-204 down-regulation induces hypoxia-inducible factor 1-alpha (HIF1α) and nuclear factor of activated T-cells cytoplasmic 2 (NFATc2) activation, resulting in the anti-apoptotic and, therefore, proliferative phenotype of PAH [14]. The gene discussed is NFATC2; the disease is pulmonary arterial hypertension.