Zhao T et al. demonstrated that rituximab-induced inhibition of STAT3 activity led to an increase in HMGB1 release and a decrease in IL-10 secretion, triggering immune responses and greatly improving the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL), suggesting that indirectly affecting the immune system rather than directly killing cells led to the elimination of DLBCL [136]. This evidence concerns the gene IL10 and diffuse large B-cell lymphoma.