Reducing the expression of HMGB1 by miR-34a, miR-181b and miR-142-3p enhances the drug sensitivity of AML cells by inhibiting autophagy; moreover, miR-142-3p directly targets HMGB1 to not only represses autophagy but also reduces P-gp to enhance the drug sensitivity of AML cells [108–110]. Here, HMGB1 is linked to acute myeloid leukemia.