HMGB1 and graft versus host disease: Moreover, the compound cyclopentylamino carboxymethylthiazolylindole (NecroX)-7 could protect mice against lethal GVHD by reciprocal regulation of regulatory T/Th1 cells, attenuating systemic HMGB1 accumulation and inhibiting the HMGB1-mediated inflammatory response [153].