However, TBI and CY can mobilize HMGB1 to the PB, and increased levels of HMGB1 correlate with increased PAI-1 after allo-HSCT, inducing transplantation-associated coagulopathy (TAC) conditions such as veno-occlusive disease (VOD) [154]. Here, HMGB1 is linked to hepatic veno-occlusive disease.