Most of the hemangiomas (11/13; 84.62%) showed < 38% of p53-positive immunoreactivity, while > 38% of p53-positive nuclei was only observed in 2/13 (15.38%) hemangiomas (see Additional file 1), in which cell proliferation was always low (MC = 0 and Ki-67 < 6%). Here, TP53 is linked to hemangioma.