Similar to the p53 index, the pp53 Ser392 index was significantly higher in the 18 cutaneous tumours (1 hemangioma and 17 HSAs) with actinic changes (median, 58.70%; IQR, 0.0–70.30%) than in the 11 hemangiomas without these histological changes (median, 0.0%; IQR, 0.0%; Fig. 5c). The gene discussed is TP53; the disease is hemangioma.