In addition, the p53 index was significantly higher in the 18 vascular tumours (1 hemangioma and 17 HSAs) with actinic changes (median, 73.94%; IQR, 66.05–82.83%) than in 11 hemangiomas without these histological changes (median, 0.0%; IQR, 0.0–11.17%; Fig. 4c). The gene discussed is TP53; the disease is hemangioma.