In our prior report, we also confirmed that prophylactic G-CSF was associated with reduced frequencies of neutropenia, febrile neutropenia, and grade 4/5 febrile neutropenia in patients divided by the starting dose of cabazitaxel (15 to < 20, 20 to < 25, or ≥ 25 mg/m2). This evidence concerns the gene CSF3 and Decreased total neutrophil count.