Compared with control group (C) and negative control group (NC), lncRNA CCHE1 silencing significant inhibited, while ROCK1 overexpression significantly promoted the migration (Fig. 5b) and invasion (Fig. 5c) of cells of both MG-63 and U2OS human osteosarcoma cell lines (p < 0.05). Here, CCEPR is linked to osteosarcoma.