Some agents that directly target macrophages and macrophage polarization, for example, injection of genetically overexpressed IL-4 macrophages [91] or transfusion of IL-4/IL-13-differentiated bone-marrow macrophages [92] have shown a consequent M2 macrophage phenotype and reduction of the degree of renal glomerular inflammation and injury in rodents with nephrotoxic nephritis. The gene discussed is IL4; the disease is inflammatory response.