Deficiency of TLR4 protects against liver injury in various animal models including bile duct ligation and experimental alcoholic and non-alcoholic steatohepatitis; similar findings are also observed in mice deficient in CD14, a TLR4-binding protein, and MyD88 and Trif, TLR4 adaptor molecules, together indicating a critical role for TLR4 in liver injury [29]. The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatohepatitis.