Blockage of NLRP3 attenuates macrophage infiltration, M1 polarization, decrease in gene expression of connexins, TGF-β, connective tissue growth factor and α-smooth muscle actin, reduction of extracellular matrix deposition, and prevents renal fibrosis and loss of renal function [48, 54, 55]. Here, TGFB1 is linked to renal fibrosis.