HMGB1 and cancer: Additionally, ICRP induced immunogenic cell death (ICD) alone or in combination with oxaliplatin in the murine model B16F10 [9]; this immunogenicity of cancer cell death relies on the antigenicity of the neoantigens expressed by dead cancer cells and the release of damage-associated molecular patterns (DAMPs) such as calreticulin (CRT), ATP and HMGB1 [10].