Iracheta-Vellve A et al. manifested that agonists of FXR and TGR5 (OCA, INT-767 and INT-777) can reduce the expression of inflammatory cytokine in animal models of alcoholic liver disease by inhibiting macrophage inflammation through activation of protein kinase A induced by cyclic adenosine monophosphate (cAMP) [40]. The gene discussed is NR1H4; the disease is alcoholic liver diseases.