The significant factors were male, hypertension, decreased hemoglobin, renal impairment, lower albumin, increased uric acid and triglyceride, more 24 h urinary protein, decreased C3 level and increased C4 level, mesangial hypercellularity, tubular atrophy or interstitial fibrosis, and C1q deposition. This evidence concerns the gene C4A and hypertensive disorder.