TGF-β1-mediated fibrosis and prevention of proper muscle tissue regeneration is also sustained by the increased expression of connective tissue growth factor (CTGF/CCN2) in DMD patients and mdx mice, where CTGF is mainly detected in regenerating fibers and in the interstitium between damaged fibers [110]. Here, TGFB1 is linked to Duchenne muscular dystrophy.