Other frequently altered transcriptional mechanisms in mouse NASH models, which were not previously associated with human NASH, included PPARδ, HIF1α, MED1, NCOA1, NCOA2, SMARCA4, FOXO3, HDAC2, STAT5b, and STAT6 (Table 4). This evidence concerns the gene HIF1A and metabolic dysfunction-associated steatohepatitis.