Other frequently altered transcriptional mechanisms in mouse NASH models, which were not previously associated with human NASH, included PPARδ, HIF1α, MED1, NCOA1, NCOA2, SMARCA4, FOXO3, HDAC2, STAT5b, and STAT6 (Table 4). Here, STAT5B is linked to metabolic dysfunction-associated steatohepatitis.