Finally, the transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), which is elevated in a NASH mouse model, enhances TGFβ/SMAD signaling by directly binding to SMAD3 and preventing its ubiquitination and degradation [167]. This evidence concerns the gene SMAD3 and metabolic dysfunction-associated steatohepatitis.