Nonetheless, the lipogenic role of Xbp1 is demonstrated using a mouse model with a liver-specific ablation of Xbp1 following WD, whereby the loss of Xbp1 is associated with reduced steatosis but enhanced liver injury and fibrosis with the upregulation of type-I collagen α1 (Colα1), TGFβ1, CHOP, and p-JNK [38,143]. This evidence concerns the gene XBP1 and Wilson disease.