YAP is expressed in hepatocytes and activates the expression of proteins that promote fibrosis (ColL1α1, TIMP1, TGFβ2) and inflammation (TNFα, IL-1β), which stimulate the expansion of myofibroblasts and the recruitment of immune cells, exacerbating liver fibrosis [174]. This evidence concerns the gene YAP1 and Hepatic fibrosis.