The cancer-associated p53 mutants include missense, frameshift, truncation, and deletion mutations, most of which are missense mutations (~74%), a single amino acid substitution that usually occurs in the p53 DBD, including the hotspot mutants, such as R175H, G245S, R248Q, R248W, R249S, R273H, R273C, and R282W. Here, TP53 is linked to cancer.