ASGR1 and hepatocellular carcinoma: Zhang and colleagues, for instance, designed a nanocarrier based on the active targeting of asialoglycoprotein receptor (ASGPR) using amino-modified MSNs conjugated with lactobionic acid (LA), for the co-delivery of sorafenib and vascular endothelial growth factor (VEGF)-targeted siRNAs (siVEGF) to hepatocellular carcinoma (HCC) [49].