Morak et al. [25] screened MUTYH in 85 patients with abnormal IHC but no detectable germline mutations in MMR genes: one patient (1%) showed a biallelic MUTYH germline mutation, accompanied by two somatic MSH2 mutations in a MSH2/MSH6-deficient tumor (a sebaceous gland carcinoma). This evidence concerns the gene MRC1 and sebaceous adenocarcinoma.