Apoptosis signaling begins in one of two ways: the intrinsic apoptotic signaling pathway mainly integrates various signals in cancers, like the Bcl-2-like family of proteins initiates a pathway through the mitochondria and cytochrome c, after which caspase 9 is activated and the extrinsic apoptotic signaling such as the Fas receptor and TNF-related apoptosis inducing ligand (TRAIL) initiates a caspase activation [72,73,74]. Here, TNFSF10 is linked to cancer.