In addition, somatic activating mutations of the PI3K/AKT/mTOR pathway may result in <i>PIK3CA</i>-related overgrowth spectrum diseases, including CLOVES (Congenital Lipomatous Overgrowth, Vascular malformation, Epidermal nevi, Skeletal abnormalities/Scoliosis) syndrome. The gene discussed is PIK3CA; the disease is vascular malformation.