Their linked phenotypes show significant variability in age at onset, severity, and a range of clinical features including those limited to the macula, such as adult-onset vitelliform macular dystrophy (AVMD, MIM 608161), butterfly patterned dystrophy (PD, MIM 169150), or central areolar choroidal dystrophy (CACD, MIM 613105), and those with more widespread disorders, such as retinitis pigmentosa 7 (RP, MIM 608133) or retinitis punctata albescens (MIM 136880) or digenic RP caused by heterozygous mutations in Retinal Outer Segment Membrane Protein 1 (ROM1) and PRPH2 genes in conjunction. The gene discussed is ROM1; the disease is retinitis pigmentosa.