Amyotrophic lateral sclerosis 10 (ALS10; OMIM #612069), also known as frontotemporal lobar degeneration with TDP43 inclusions, TARDBP-related (FTLD-TDP, TARDBP-RELATED), is caused by heterozygous mutations in the TAR DNA binding protein gene (TARDBP), which encodes the TDP-43 protein. This evidence concerns the gene TARDBP and frontotemporal dementia.