TNFRSF1A and cancer: Other anti-cancer drugs, on the other hand, induce intrinsic apoptotic pathways against A549 cells through the activation of tumor-necrosis factor receptor 1 (TNFR1) and the Fas-associated death domain (FADD), leading to cell death by caspase-3, without stimulating the survival path of the receptor-interacting protein (RIP) [11].